Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder

Objective: The aim of this study was to evaluate the relationship between apelin-36 and oxidative parameters Generalized Anxiety Disorder (GAD). Apelin which prevents hippocampal neuronal death is an endogenous ligand for G protein bound APJ receptors in central nervous system. Oxidative Stress were occurred by free radicals caused apoptosis hypothlamus, hippocampus amygdala regions Central Nervous System (CNS). Methods: In study, 61 patients diagnosed generalized anxiety disorder at psychiatry polyclinic 55 control subjects enrolled. Structured Clinical Interview DSM-IV Axis I Disorders (SCID-I) Hamilton Rating Scale (HARS) used they filled healthy individuals. Serum level measured using ELISA kit. Total antioxidant status (TAS) Oxidant Status (TOS) serum automated data analyzed SPSS. Results: It found that apelin-36, TOS stress index (OSI) levels significantly lower patients’ group than controls. addition, negative correlation detected apelin 36 HARS scores, OSI values group. TAS as similar patient There no Conclusion: it low GAD. According results, Apelin-36 may play a role etiopathogenesis Disorder.